Histamine is created from biological response on our body of local immune responses or in order to regulate physiological function in the gut and then can act as neurotransmitter. Histamine also created in our body response to foreign pathogens. Histamine also produce by animals in response of other disturbance or to protect them from other animals attack. In the body system, histamine is produced by basophiles and by mass cells that is found nearby connective tissue. Histamine substance created by our body in order to protect from other strange protein because by created histamine then white blood will have cell will increase the permeability of the capillaries. Histamine have colorless and hygroscopic crystals, as physical properties histamine will melt at 84oC, histamine include as polar chemicals so histamine easily dissolved in water or ethanol or alcohol but not in non polar chemicals like oil and fat. In the solution with water histamine will form as Nπ-histamine and Nτ-hi