Insect have more species (over one million already described) than any other form of animal life and are in many ways the most indestructible form. About 1 percent of the species offer hazard to human and animals. Human and pests fight a continuous battle for food and shelter. Insects alone claim about 10 % of our crops in US, and about 14 percent in worldwide, various misery causing diseases are carried by insect malaria, yellow fever, typhus, and plague to name a few. For us to survive at current population levels, pesticides must be used and new ones constantly developed. When insecticide applied widely, all but a few of the local insects are destroyed, but the remaining ones are those most resistant to the destroying agent. After destroying generation, this selection makes the surviving insects increasingly resistant to the destroying agent. Eventually, complete resistance may occur. This phenomenon is seen with medical product, and all types of pesticides. In an effort to retard