Nitroglycerin is a pale yellow oil, highly unstable and toxic, first made in 1846 by the Italian chemist Ascario Sobrero. Alfred Nobel's is the first scientist who attempt in 1863 to use as explosive power were unsuccessful because the extremely unstable nature of substance preclude its safe transport, storage, and employment. In 1864 then Nobel produced solid preparations by mixing nitroglycerin with porous substances such as kieselguhr, thus allowing the explosive to be employed as safe, stable, blasting agent, namely dynamite.

In medicine, nitroglycerin is used as a vasodilator to reduce arterial tension, especially for the treatment of heart diseases such as angina pectoral. The basic pharmacological action of nitroglycerin is the nonspecific relaxation of all smooth muscle. A throbbing headache, experienced by dynamite factory worker, is the most characteristic symptom of nitroglycerin toxicity. After sometime, immunity to the poison develops; immunity is rapidity lost, however, after exposure is discontinued.


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